Hydroxypropyl Beta Cyclodextrin Powder

Hydroxypropyl beta cyclodextrin powder (HP-β-CD or HPBCD) is a water-soluble derivative of beta-cyclodextrin widely used as a complexing agent and solubilization excipient in pharmaceutical development, cosmetic formulations, and specialty chemical applications. Its modified molecular structure provides greater aqueous solubility than native beta-cyclodextrin while retaining the ability to form inclusion complexes with compatible molecules.

CHEN LANG BIO TECH manufactures and supplies hydroxypropyl beta cyclodextrin for customers who require consistent material specifications, reliable quality control, and commercial quantities for formulation development and industrial production. We support international ingredient buyers with technical documentation, sample evaluation, and bulk supply arrangements.

Our HP-β-CD products are intended for professional formulation and manufacturing applications, with suitability determined by the selected grade, product specifications, and applicable regulatory requirements.

Hydroxypropyl Beta Cyclodextrin Specifications

Hydroxypropyl beta cyclodextrin is produced by chemically modifying beta-cyclodextrin through hydroxypropyl substitution. The resulting material is not a single molecular species but a distribution of substituted cyclodextrin molecules, making substitution characteristics and impurity control particularly important during supplier qualification.

The following table summarizes the general product identity and technical parameters relevant to procurement.

Parameter	Product Information
Product Name	Hydroxypropyl Beta Cyclodextrin
Abbreviation	HP-β-CD / HPBCD
CAS Number	128446-35-5
Chemical Classification	Hydroxypropylated beta-cyclodextrin
Appearance	White or almost white powder
Solubility	Highly soluble in water; grade-dependent
Molecular Weight	Average molecular weight varies with substitution
Degree of Substitution	According to product grade and specification
Main Function	Solubilizing and inclusion complexing agent
Applications	Pharmaceutical formulation research, cosmetics, specialty formulations
Packaging	1–5 kg aluminum foil bags; 25 kg paper drums, subject to confirmation
Documentation	COA, TDS, SDS

The applicable hydroxypropyl beta cyclodextrin specifications should be reviewed against the intended formulation rather than selected solely by appearance or a nominal purity percentage.

For technical evaluation, buyers should consider the substitution profile, residual starting materials, moisture, and other grade-specific quality attributes. A batch-specific Certificate of Analysis provides the appropriate basis for confirming whether the supplied material meets an agreed specification.

What Is Hydroxypropyl Beta Cyclodextrin?

Hydroxypropyl beta cyclodextrin is a chemically modified cyclodextrin derived from beta-cyclodextrin, a cyclic oligosaccharide composed of seven glucose units.

The cyclodextrin molecule has a relatively hydrophobic internal cavity surrounded by a hydrophilic exterior. This structural arrangement allows compatible guest molecules, or portions of those molecules, to associate with the cavity through non-covalent interactions.

Introducing hydroxypropyl groups changes the physicochemical properties of the original cyclodextrin structure. One of the most important differences is improved aqueous solubility, which makes HP-β-CD particularly useful in formulations where native beta-cyclodextrin has practical limitations.

Unlike conventional surfactants, HP-β-CD does not primarily rely on micelle formation to improve apparent solubility. Its performance is associated with molecular inclusion and related complexation equilibria.

These characteristics explain why hydroxypropyl beta cyclodextrin water solubility and complexation behavior are central considerations when selecting the material for commercial formulation work.

Functional Properties of Hydroxypropyl Beta Cyclodextrin

Aqueous Solubility and Formulation Flexibility

Native beta-cyclodextrin has relatively limited solubility in water, which can restrict its usefulness in concentrated aqueous systems. Hydroxypropyl substitution disrupts aspects of the original molecular packing and generally produces a substantially more water-soluble derivative.

This improved solubility can provide greater flexibility when developing aqueous formulations containing compatible, poorly soluble ingredients.

However, the solubility of HP-β-CD itself should not be confused with the solubilization capacity of a particular active ingredient. The latter depends on molecular compatibility, complex stability, cyclodextrin concentration, and formulation conditions.

Inclusion Complex Formation

The formation of a cyclodextrin inclusion complex involves the association of a compatible guest molecule with the cyclodextrin cavity.

The interaction is generally reversible and does not require the formation of a new covalent chemical bond. Complexation may influence the apparent aqueous solubility, distribution, or chemical stability of a guest ingredient, depending on its molecular characteristics.

Not every poorly soluble ingredient forms a useful complex with HP-β-CD. Molecular dimensions, polarity, competing formulation components, and binding affinity all affect the outcome.

For this reason, phase-solubility studies and formulation-specific analytical testing are valuable when evaluating a new ingredient system.

Solubilization and Ingredient Stability

As a hydroxypropyl beta cyclodextrin solubilizer, HP-β-CD can increase the apparent aqueous solubility of selected compounds through complex formation.

This property is useful when a formulation requires a greater concentration of a poorly water-soluble ingredient than can be achieved in water alone.

Complexation may also reduce the exposure of certain molecular regions to the surrounding environment, potentially improving stability under specific conditions. Nevertheless, protection against oxidation, light, or degradation should be demonstrated experimentally rather than assumed.

The practical performance of HP-β-CD must therefore be assessed in the complete formulation, including its pH, temperature, ingredient concentration, and storage conditions.

Hydroxypropyl Beta Cyclodextrin Applications

The commercial value of HP-β-CD lies in its ability to address specific formulation challenges. Its suitability depends on the selected material grade, the guest ingredient, and the requirements of the finished product.

Cosmetic and Personal Care Formulations

In cosmetic formulation development, HP-β-CD may be used to improve the incorporation of compatible ingredients that exhibit limited aqueous solubility.

Potential applications include skincare serums, aqueous cosmetic systems, and specialty formulations involving selected fragrance components or functional ingredients.

For cosmetic manufacturers evaluating hydroxypropyl beta cyclodextrin cosmetic grade, important considerations include ingredient compatibility, product clarity, stability, microbiological quality, and compliance with the intended market’s cosmetic ingredient requirements.

Complexation may also influence the availability of an ingredient within a formulation. Consequently, an increase in apparent solubility does not automatically translate into improved skin delivery or greater cosmetic performance.

CHEN LANG BIO TECH supports cosmetic ingredient buyers with material specifications and documentation for formulation assessment.

Pharmaceutical Excipient Development

HP-β-CD is also investigated and used as a complexing excipient in pharmaceutical formulation systems, particularly where aqueous solubility presents a development challenge.

A suitably qualified hydroxypropyl beta cyclodextrin pharmaceutical grade may be considered for certain dosage-form applications, subject to the relevant quality requirements, route of administration, and regulatory assessment.

Its ability to form inclusion complexes can support formulation studies involving selected poorly water-soluble drug substances.

However, pharmaceutical use requires a more extensive qualification process than general industrial use. Buyers must evaluate applicable pharmacopoeial requirements, impurity limits, microbiological specifications, and route-specific safety considerations.

Not all HP-β-CD grades are interchangeable, and a general-purpose product should not be assumed suitable for pharmaceutical manufacturing or parenteral applications.

When sourcing a hydroxypropyl beta cyclodextrin excipient, customers should clearly identify their intended dosage form and required quality standard before requesting a commercial quotation.

Specialty Formulation and Research Applications

Beyond cosmetics and pharmaceutical development, HP-β-CD is used in research involving molecular inclusion, solubility enhancement, and guest–host interactions.

It can be evaluated in specialty chemical formulations where the behavior of a compatible organic compound in an aqueous environment is important.

Research applications may involve comparing different cyclodextrin derivatives, investigating complexation efficiency, or studying the effect of substitution characteristics on formulation performance.

For industrial buyers, laboratory results should be translated into practical process requirements, including mixing conditions, ingredient loading, reproducibility, and finished-product stability.

Hydroxypropyl Beta Cyclodextrin vs Beta Cyclodextrin

The main difference between hydroxypropyl beta cyclodextrin and native beta-cyclodextrin is the chemical modification of the cyclodextrin structure, which significantly changes its aqueous solubility and formulation behavior.

Property	Beta Cyclodextrin	Hydroxypropyl Beta Cyclodextrin
Molecular Structure	Native cyclic oligosaccharide	Hydroxypropyl-substituted derivative
Water Solubility	Relatively limited	Generally much higher
Inclusion Complex Formation	Yes	Yes
Substitution Profile	Not applicable	Important quality parameter
Aqueous Formulation Flexibility	More limited	Often greater
Material Selection	Based on application and solubility requirements	Based on substitution, complexation, grade, and formulation requirements

When comparing hydroxypropyl beta cyclodextrin vs beta cyclodextrin, higher water solubility is an important advantage, but it does not establish superior performance for every guest molecule.

The preferred material should be selected through compatibility studies, technical specifications, and an assessment of the finished formulation.

Manufacturing and Quality Control

As a hydroxypropyl beta cyclodextrin manufacturer, CHEN LANG BIO TECH places particular emphasis on material consistency and the technical parameters that influence downstream formulation performance.

Hydroxypropyl beta cyclodextrin is generally produced through controlled hydroxypropylation of beta-cyclodextrin, followed by purification, concentration, drying, and quality testing.

The manufacturing process must account for the distribution of substituted molecules rather than simply targeting a single nominal assay value.

Substitution Profile and Molecular Characteristics

The HPBCD degree of substitution is an important technical consideration because hydroxypropyl modification influences molecular weight distribution, solubility, and complexation behavior.

Two related measurements may be encountered in technical documentation: degree of substitution (DS) and molar substitution (MS). DS describes the average number of substituted hydroxyl positions per glucose unit, while MS describes the average number of hydroxypropyl units introduced per glucose unit, including possible extended substituent chains.

These parameters should not be treated as interchangeable without understanding the analytical method and reporting convention.

Batch Quality and Documentation

Depending on the applicable grade, quality evaluation may include identification, substitution characteristics, residual beta-cyclodextrin, process-related impurities, moisture, and microbiological testing.

Our quality documentation is intended to help customers assess material identity, specification compliance, and consistency between production batches.

Available documentation can be discussed during supplier qualification, including the current COA, technical data sheet, and safety data sheet.

Bulk Supply, Packaging and Lead Time

CHEN LANG BIO TECH supports international customers requiring bulk hydroxypropyl beta cyclodextrin for formulation development, production trials, and recurring commercial orders.

Packaging arrangements may include 1–5 kg aluminum foil bags for smaller quantities and 25 kg paper drums for larger shipments, subject to the confirmed product specification and order requirements.

Materials should be stored in tightly closed containers in a dry environment, protected from moisture and unnecessary contamination. Storage conditions and shelf life should follow the applicable product documentation.

Commercial quotations are prepared according to the required grade, order quantity, packaging, and shipping destination.

Customers can contact our sales team to confirm sample availability, minimum order quantity, production lead time, and international shipping arrangements.

Why Choose CHEN LANG BIO TECH as Your HP-β-CD Supplier?

Selecting a hydroxypropyl beta cyclodextrin supplier involves more than comparing prices. The material must be suitable for the intended formulation, and its critical quality attributes should remain consistent from qualification samples through commercial deliveries.

CHEN LANG BIO TECH combines ingredient manufacturing experience, quality testing resources, and international raw material supply services to support customers throughout the purchasing process.

Our approach emphasizes clear technical communication, practical specification review, and coordination between sample evaluation and commercial procurement.

For customers developing new formulations, we recommend confirming the required substitution characteristics, application grade, and relevant impurity limits before finalizing an order.

This helps reduce the risk of selecting a material that meets a general product description but does not satisfy the technical requirements of the finished formulation.

Frequently Asked Questions

Is hydroxypropyl beta cyclodextrin soluble in water?

Yes. HP-β-CD generally exhibits substantially higher aqueous solubility than native beta-cyclodextrin. Actual solubility depends on the material grade, substitution characteristics, temperature, and test conditions. Buyers should consult the current technical specification when evaluating concentrated formulations.

What is the degree of substitution of HPBCD?

The substitution profile depends on the manufacturing process and product grade. Degree of substitution and molar substitution describe related but distinct characteristics. Customers should review the applicable specification and analytical method rather than assuming that all HPBCD materials have the same substitution profile.

Is hydroxypropyl beta cyclodextrin suitable for cosmetic and pharmaceutical applications?

HP-β-CD can be used in cosmetic formulation development and is established as an excipient in certain pharmaceutical applications. However, suitability depends on the specific grade, intended use, applicable regulatory requirements, and supporting documentation. Pharmaceutical-grade compliance must be verified for the material being supplied.

What is the MOQ for hydroxypropyl beta cyclodextrin powder?

The minimum order quantity depends on the selected grade and packaging requirements. CHEN LANG BIO TECH can discuss sample quantities, formulation trial orders, and commercial supply arrangements based on customer requirements.

What affects hydroxypropyl beta cyclodextrin price?

Hydroxypropyl beta cyclodextrin price depends on factors such as material grade, substitution specifications, quality requirements, order volume, packaging, and shipping destination. Customers should provide their target specification and purchasing quantity to receive an accurate quotation.

Can I request a COA before placing an order?

Yes. Customers can request available technical documentation, including the current Certificate of Analysis, technical data sheet, and safety data sheet, to support supplier evaluation and material qualification.

Request Hydroxypropyl Beta Cyclodextrin COA & Bulk Quotation

CHEN LANG BIO TECH supplies hydroxypropyl beta cyclodextrin powder to international ingredient distributors, cosmetic manufacturers, formulation laboratories, and qualified industrial buyers.

For a quotation, please share your intended application, required grade, target specifications, purchasing quantity, and delivery destination. Our team will assist with product documentation, sample availability, packaging options, and commercial supply arrangements.

Email: extract@chenlangbio.com

Whatsapp: +86-17782478823

Contact CHEN LANG BIO TECH to request technical specifications, COA, and bulk pricing for your next formulation or manufacturing project.